Triethylamine → 4-{2-[(6-{[4-(Dimethylphosphoryl)phenyl]amino}pyrimidin-4-yl)-amino]ethyl}benzene sulfonamide

Participants

Reaction Steps

To a solution of 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine (prepared as in Example 59: 0.12 mmol) in 2 mL of ethanol is added 50 μL of triethylamine and 4-(2-aminoethyl)benzene-sulfonamide (23 mg, 0.12 mmol). The mixture can be microwaved at 120 degrees until formation of the desired compound. The reaction mixture can be filtered through a syringe filter and purified by prep-HPLC.

Provenance & Evidence