HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[4-(dimethylphosphoryl)phenyl]-N'-(morpholin-4-yl)pyrimidine-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-Aminomorpholine | HCID 20315 | — |
| Reactant | 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine | HCID 86668807 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[4-(dimethylphosphoryl)phenyl]-N'-(morpholin-4-yl)pyrimidine-4,6-diamine | HCID 68156854 | — |
Reaction Steps
To a solution of 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine (prepared as in Example 59: 0.12 mmol) in 2 mL of ethanol is added 50 μL of triethylamine and 4-Aminomorpholine (12 mg, 0.12 mmol). The mixture is microwaved at 120 degrees until formation of the desired compound. The reaction mixture can then be filtered through a syringe filter and purified by prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012462B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-1190489a520646f3b93a9efd447a1bac |
| Source note | uspto-grants-2015_04 |