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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1472068Generated: October 30, 2026

4-(Dimethylphosphoryl)-2-fluoroaniline → N2-[4-(dimethylphosphoryl)-2-fluorophenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

https://huagongshe.com/reaction/1472068

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Dimethylphosphoryl)-2-fluoroanilineHCID 67052680—
Reactant2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amineHCID 86668814—
ProductN2-[4-(dimethylphosphoryl)-2-fluorophenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamineHCID 68165248—

Reaction Steps

This compound can be prepared as described in Example 80 by reacting 2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine with 4-(dimethylphosphoryl)-2-fluoroaniline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09012462B2
Source datasetuspto-grants-2015_04
ORD IDord-3841ea48a18749379be6716e7c59bb9b
Source noteuspto-grants-2015_04