HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → N-[4-(dimethylphosphoryl)phenyl]-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-chloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine | HCID 86668817 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[4-(dimethylphosphoryl)phenyl]-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-2-amine | HCID 68157393 | — |
Reaction Steps
To a solution of 4-chloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine (prepared as in Example 92: 0.12 mmol) in 2 mL of ethanol is added 50 μL of triethylamine and 1-Phenylpiperazine (19 mg, 0.12 mmol). The mixture is microwaved at 120 degrees until formation of the desired compound. The reaction mixture is filtered through a syringe filter and purified by prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012462B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-9cb2729d7f184bf8b02b0044f29b0afd |
| Source note | uspto-grants-2015_04 |