HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3,6-dichloro-N-[2-(propan-2-ylsulfonyl)phenyl]-1,2,4-triazin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3,5,6-Trichloro-1,2,4-triazine | HCID 12262403 | — |
| Reactant | 2-(Propane-2-sulfonyl)aniline | HCID 12646366 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,6-dichloro-N-[2-(propan-2-ylsulfonyl)phenyl]-1,2,4-triazin-5-amine | HCID 86668822 | — |
Reaction Steps
To a solution of 1-Amino-2-(isopropylsulphonyl)benzene (350 mg, 1.6 mmol) and 3,5,6-trichloro-1,2,4-triazine (1.6 mmol) in CH2Cl2, is added triethylamine (2 mmol). The reaction mixture is allowed to cool to room temperature, dissolved in dichloromethane and washed with an aqueous solution of Na2CO3. The dichloromethane extract is dried over MgSO4 and evaporated. The crude product is purified by Prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012462B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-6afe7b09fa1c478fb522c07c80373ab1 |
| Source note | uspto-grants-2015_04 |