Potassium Phosphate, Tribasic → HCID 67052695, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
Reactant	HCID 67052709	HCID 67052709	—
Reactant	methylphosphonoylmethane	HCID 178503022	—
Catalyst	palladium(II) acetate	HCID 167845	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 67052695	HCID 67052695	—

Reaction Conditions

Temperature	110 °C

Reaction Steps

To a stirring solution of 4-bromo-1-nitro-2-(propan-2-ylsulfonyl)benzene (0.44 g, 1.6 mmol) and Dimethyl Phosphine oxide (0.15 g, 1.9 mmol) in 1 mL of DMF, was added Potassium Phosphate (0.37 g, 1.8 mmol), Pd(OAc)2 (18 mg, 0.08 mmol), Xantphos (55 mg, 0.10 mmol). The reaction mixture was stirred at 110 degrees C overnight. The reaction mixture was cooled to room temperature and filtered through celite. The desired product was isolated through prep-HPLC to yield a brownish yellow solid (0.24 g, 55% yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09012462B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-0e9a2671960b48a2b4c55d34fd5079f9
Source note	uspto-grants-2015_04