HCID 57703891, compound → HCID 16730513, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3,5-difluoro-benzenesulfonyl)-6,6-dimethyl-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-2-carboxylic acid ethyl ester (1.6 g, 3 mmol) in MeOH (60 mL) and triethylamine (5 mL) was heated at 60° C. for 2 hours. The reaction mixture was then evaporated to dryness and the crude residue crystallized from ethyl acetate, filtered, washed with diethyl ether and dried under vacuum affording the title compound as white solid (1.2 g).

Provenance & Evidence