HCID 86630517, compound → HCID 24751744, compound

Participants

Reaction Steps

To a solution of ethyl 5-(3,5-difluoro-benzenesulfonyl)-3-(2-{[(S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-pyrrolidine-2-carbonyl]-amino}-4-morpholin-4-yl-benzoylamino)-6,6-dimethyl-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-2-carboxylic acid ethyl ester (0.3 g, 0.32 mmol) in MeOH (10 mL) and dichloromethane (3 mL), piperidine (1 mL) was added and the reaction mixture stirred at room temperature for 12 hours. After evaporation to dryness, the residue was washed with petroleum ether and purified by flash chromatography on silica gel, using a mixture dichloromethane-MeOH 95:5 as the eluant, affording the title compound as pale yellow powder (0.15 g).

Provenance & Evidence