反应详情

50.7 g (0.5 mol) sec.-Butyl isocyanate were placed in a 500 ml vessel at ambient temperature and 64.1 g (0.5 mol) 2,3-dimethylcyclohexanol were added. The reaction mixture was heated for 5 h to 150° C., cooled and subsequently 100 ml water were added. After refluxing for one hour the solution was cooled down, the phases separated and extracted once with MTBE (methyl tert.-butyl ether). The raw product was purified by distillation to yield 60.2 g product as a mixture of isomers with a purity of 99.6%.

1. temperatureThe reaction mixture was heated for 5 h to 150° C.
2. temperaturecooled
3. temperatureAfter refluxing for one hour the solution
4. temperaturewas cooled down
5. customthe phases separated
6. extractionextracted once with MTBE (methyl tert.-butyl ether)
7. distillationThe raw product was purified by distillation