HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 19012449, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 6-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 11423879 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19012449 | HCID 19012449 | — |
Reaction Steps
intermediate (24a) (180 mg, 1 mmol) was dissolved in MeOH (10 mL). Aqueous ammonia (1 mL) was added, followed by wet Raney Nickel (100 mg). The mixture was stirred at room temperature under hydrogen for 3 hours. The mixture was then filtered and the filtrate evaporated to yield intermediate (24b) (157 mg, 870 μmol, which was used without further purification. MS m/z: [M+H+] calcd for C10H17N2O, 181.3; found 181.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012485B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-b58c472a39bb45d5b77a5d163dbbdf28 |
| Source note | uspto-grants-2015_04 |