Metformin Hydrochloride → HCID 178484382, compound

Metformin hydrochloride (331.25 g, 2 moles) was weighed into a 4000 mL beaker containing a stir bar. 1N KOH (1980 mL, 1.998 moles) was added, the beaker was covered, and the mixture was stirred for 2 h. The solids were collected by vacuum filtration, and the filtrate was concentrated to a damp solid. Isopropanol (500 mL) was added and after brief swirling, the mixture was concentrated. The residual white solid was dried for 16 h in a vacuum oven (yield: 269.08 g).

1. additioncontaining a stir bar
2. filtrationThe solids were collected by vacuum filtration
3. concentrationthe filtrate was concentrated to a damp solid
4. additionIsopropanol (500 mL) was added
5. concentrationafter brief swirling, the mixture was concentrated
6. customThe residual white solid was dried for 16 h in a vacuum oven (yield: 269.08 g)

ORD record

ord-da19efdba62c4beda15d48f074c4b8f0

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09012507B2