3-Pyridinylboronic acid → (S)-1-fluoro-3-(2-fluoropyridin-4-yl)-7-(pyridin-3-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine

Participants

Role	Name	HCID	Charge
Reactant	3-Pyridinylboronic acid	HCID 2734378	—
Reactant	2-Fluoropyridine-4-boronic acid	HCID 2783396	—
Reactant	(S)-7-bromo-3-chloro-1-fluoro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine	HCID 58465925	—
Product	(S)-1-fluoro-3-(2-fluoropyridin-4-yl)-7-(pyridin-3-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine	HCID 58465937	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A1 above, but using intermediate 15B, 3-pyridylboronic acid and 2-fluoropyridine-4-boronic acid. MS m/z=458.0 [M+H]+. Calculated for C25H17F2N5O2: 457.14

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09012446B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-6e6b51d351f6413ab508b065f436b5fb
Source note	uspto-grants-2015_04