2-Fluoropyridine-3-boronic acid → HCID 58465929, compound

HRID 1472464Notes

Reaction equation

HRID 1472464 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[C:10]([F:23])[C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:24][C:25]1[C:30](B(O)O)=[CH:29][CH:28]=[CH:27][N:26]=1.[CH3:34][C:35]1[CH:40]=[C:39](B2OC(C)(C)C(C)(C)O2)[CH:38]=[CH:37][N:36]=1>>[F:23][C:10]1[C:9]2[O:8][C:5]3[C:4]([C@:15]4([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]4)[C:14]=2[CH:13]=[C:12]([C:39]2[CH:38]=[CH:37][N:36]=[C:35]([CH3:34])[CH:40]=2)[N:11]=1)=[CH:3][C:2]([C:30]1[C:25]([F:24])=[N:26][CH:27]=[CH:28][CH:29]=1)=[CH:7][CH:6]=3

Participants

4

Reactant 3

HCID 27832702-Fluoropyridine-3-boronic acidHCID 164142742-Methylpyridine-4-boronic acid pinacol esterHCID 86658393HCID 86658393, compound

Product 1

HCID 58465929HCID 58465929, compound

Procedure

The titled compound was synthesized by steps analogous to those described in method A1 above, but using (Intermediate 17B), 2-fluoropyridin-3-ylboronic acid and 2-methylpyridine-4-boronic acid pinacol ester.

Sources & evidence

ORD record
ord-1283e479b7c14421b8708ac583a20ed0
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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