3,3-Dimethyl-1-butyne → HCID 58465916, compound

HRID 1472466Notes

Reaction equation

HRID 1472466 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:23][C:24]1[C:29](B(O)O)=[CH:28][CH:27]=[CH:26][N:25]=1.[CH3:33][C:34]([CH3:38])([CH3:37])[C:35]#[CH:36]>>[CH3:33][C:34]([CH3:38])([CH3:37])[C:35]#[C:36][C:12]1[N:11]=[CH:10][C:9]2[O:8][C:5]3[C:4]([C@@:15]4([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]4)[C:14]=2[CH:13]=1)=[CH:3][C:2]([C:29]1[C:24]([F:23])=[N:25][CH:26]=[CH:27][CH:28]=1)=[CH:7][CH:6]=3

Participants

4

Reactant 3

HCID 135123,3-Dimethyl-1-butyneHCID 27832702-Fluoropyridine-3-boronic acidHCID 58465998HCID 58465998, compound

Product 1

HCID 58465916HCID 58465916, compound

Procedure

The titled compound was synthesized by steps analogous to those described in method A2 above, but using intermediate 18B, 2-fluoropyridin-3-ylboronic acid and 3,3-dimethylbut-1-yne. MS m/z=443.0 [M+H]+. Calculated for C26H23FN4O2: 442.48

Sources & evidence

ORD record
ord-ef3640c2e03d44d5b2f9fb3268cc172e
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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