2-Fluoropyridine-3-boronic acid → HCID 58465900, compound

HRID 1472467Notes

Reaction equation

HRID 1472467 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:23][C:24]1[C:29](B(O)O)=[CH:28][CH:27]=[CH:26][N:25]=1.[F:33][C:34]1[CH:39]=[C:38](B(O)O)[CH:37]=[CH:36][N:35]=1>>[F:23][C:24]1[C:29]([C:2]2[CH:3]=[C:4]3[C@@:15]4([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]4)[C:14]4[CH:13]=[C:12]([C:38]5[CH:37]=[CH:36][N:35]=[C:34]([F:33])[CH:39]=5)[N:11]=[CH:10][C:9]=4[O:8][C:5]3=[CH:6][CH:7]=2)=[CH:28][CH:27]=[CH:26][N:25]=1

Participants

4

Reactant 3

HCID 27832702-Fluoropyridine-3-boronic acidHCID 27833962-Fluoropyridine-4-boronic acidHCID 58465998HCID 58465998, compound

Product 1

HCID 58465900HCID 58465900, compound

Procedure

The titled compound was synthesized by steps analogous to those described in method A1 above, but using intermediate 18B, 2-fluoropyridin-3-ylboronic acid and 2-fluoropyridin-4-ylboronic acid. MS m/z=458.0 [M+H]+. Calculated for C25H17F2N5O2: 457.43

Sources & evidence

ORD record
ord-0454d0ec1ba5469ca14f1d3251a292aa
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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