2-Fluoropyridine-4-boronic acid → HCID 58465869, compound

HRID 1472468Notes

Reaction equation

HRID 1472468 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[N:28][CH:29]=1.[F:33][C:34]1[CH:39]=[C:38](B(O)O)[CH:37]=[CH:36][N:35]=1>>[F:23][C:24]1[CH:25]=[C:26]([C:2]2[CH:3]=[C:4]3[C@@:15]4([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]4)[C:14]4[CH:13]=[C:12]([C:38]5[CH:37]=[CH:36][N:35]=[C:34]([F:33])[CH:39]=5)[N:11]=[CH:10][C:9]=4[O:8][C:5]3=[CH:6][CH:7]=2)[CH:27]=[N:28][CH:29]=1

Participants

4

Reactant 3

HCID 27833962-Fluoropyridine-4-boronic acidHCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 58465998HCID 58465998, compound

Product 1

HCID 58465869HCID 58465869, compound

Procedure

The titled compound was synthesized by steps analogous to those described in method A1 above, but using intermediate 18B, 5-fluoropyridin-3-ylboronic acid and 2-fluoropyridin-4-ylboronic acid. MS m/z=458.0 [M+H]+. Calculated for C25H17F2N5O2: 457.43

Sources & evidence

ORD record
ord-5c42f3edac2646a591e5d6c41cc22594
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

Loading…