4,4-Difluoropiperidine → HCID 58465911, compound

HRID 1472470Notes

Reaction equation

HRID 1472470 reaction equation
Br[C:2]1[CH:15]=[C:14]2[C:5]([O:6][C:7]3[C:8]([F:24])=[CH:9][C:10](OC)=[CH:11][C:12]=3[C@@:13]32[N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)=[CH:4][CH:3]=1.[F:25][C:26]1[C:31](B(O)O)=[CH:30][CH:29]=[CH:28][N:27]=1.[F:35][C:36]1([F:42])[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>>[F:35][C:36]1([F:42])[CH2:41][CH2:40][N:39]([C:10]2[CH:9]=[C:8]([F:24])[C:7]3[O:6][C:5]4[C:14](=[CH:15][C:2]([C:31]5[C:26]([F:25])=[N:27][CH:28]=[CH:29][CH:30]=5)=[CH:3][CH:4]=4)[C@:13]4([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]4)[C:12]=3[CH:11]=2)[CH2:38][CH2:37]1

Participants

4

Reactant 3

HCID 27583524,4-DifluoropiperidineHCID 27832702-Fluoropyridine-3-boronic acidHCID 58465954HCID 58465954, compound

Product 1

HCID 58465911HCID 58465911, compound

Procedure

The title compound was synthesized by steps analogous to those described in method A6 above, but using intermediate 13A, 2-fluoropyridin-3-ylboronic acid and 4,4-difluoropiperidine. MS m/z=499.0 [M+H]+. Calculated for C26H22F4N4O2: 498.17

Sources & evidence

ORD record
ord-e9975133b22d480ca2f9d921c0d4933b
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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