3-Fluoropyrrolidine → (S)-4'-fluoro-2'-(2-fluoro-2-methylpropoxy)-7'-(2-fluoropyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine

Participants

Role	Name	HCID	Charge
Reactant	3-Fluoropyrrolidine	HCID 2759163	—
Reactant	2-Fluoropyridine-3-boronic acid	HCID 2783270	—
Reactant	(S)-7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465963	—
Product	(S)-4'-fluoro-2'-(2-fluoro-2-methylpropoxy)-7'-(2-fluoropyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465950	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A6 above, but using intermediate 20B, 2-fluoropyridin-3-ylboronic acid and (R)-3-fluoropyrrolidine. MS m/z=467.0 [M+H]+. Calculated for C25H21F3N4O2: 466.16

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09012446B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-c850adf6f72541d5a5c94f5dfb7b88c5
Source note	uspto-grants-2015_04