2-Fluoropyridine-3-boronic acid → (S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoropyridine-3-boronic acid	HCID 2783270	—
Reactant	3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester	HCID 11218053	—
Reactant	(S)-7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465963	—
Product	(S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465933	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A7 above, but using intermediate 20B, 2-fluoropyridin-3-ylboronic acid and 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09012446B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-7cb0e67a1c1247a0b40e595dbbe49a09
Source note	uspto-grants-2015_04