(Pyridin-4-yl)boronic acid → (S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-(pyridin-4-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine

Participants

Role	Name	HCID	Charge
Reactant	(Pyridin-4-yl)boronic acid	HCID 2734379	—
Reactant	2-Fluoropyridine-3-boronic acid	HCID 2783270	—
Reactant	(S)-7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465963	—
Product	(S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-(pyridin-4-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465953	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A7 above, but using intermediate 20B, 2-fluoropyridin-3-ylboronic acid and 4-pyridineboronic acid. MS m/z=456.8 [M+H]+. Calculated for C26H18F2N4O2: 456.14

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09012446B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-e65684cf54a946e5b601b10f8230f33d
Source note	uspto-grants-2015_04