3-Pyridinylboronic acid → (S)-4'-fluoro-2'-(2-fluoro-2-methylpropoxy)-7'-(pyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine

Participants

Role	Name	HCID	Charge
Reactant	3-Pyridinylboronic acid	HCID 2734378	—
Reactant	2-Fluoro-2-methylpropyl trifluoromethanesulfonate	HCID 12165534	—
Reactant	(S)-7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465963	—
Product	(S)-4'-fluoro-2'-(2-fluoro-2-methylpropoxy)-7'-(pyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine	HCID 58465993	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A8 above, but using intermediate 20B, pyridin-3-ylboronic acid and 2-fluoro-2-methylpropyl trifluoromethanesulfonate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09012446B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-c8fe6cb7b1064919bb9765256d0b13e1
Source note	uspto-grants-2015_04