HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinylboronic acid → (S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-flouro-7'-(pyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | 3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester | HCID 11218053 | — |
| Reactant | (S)-7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine | HCID 58465963 | — |
| Product | (S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-flouro-7'-(pyridin-3-yl)-5,6-dihydrospiro[[1,3]oxazine-4,9'-xanthen]-2-amine | HCID 58465981 | — |
Reaction Steps
The title compound was synthesized by steps analogous to those described in method A7 above, but using intermediate 20B, pyridin-3-ylboronic acid and 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012446B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-d401214616924f54ad409d65cf657b3a |
| Source note | uspto-grants-2015_04 |