HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenylboronic acid → (S)-3-(5'-amino-7-(3-fluorophenyl)-2',6'-dihydro spiro[chromeno[2,3-c]pyridine-5,3'-[1,4]oxazine]-3-yloxy)-2,2-dimethylpropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | 3-Hydroxy-2,2-dimethylpropanenitrile | HCID 13531383 | — |
| Reactant | (S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine | HCID 58465879 | — |
| Product | (S)-3-(5'-amino-7-(3-fluorophenyl)-2',6'-dihydro spiro[chromeno[2,3-c]pyridine-5,3'-[1,4]oxazine]-3-yloxy)-2,2-dimethylpropanenitrile | HCID 58465895 | — |
Reaction Steps
The title compound was synthesized by steps analogous to those described in Method A4, but using Intermediate 10B, 3-hydroxy-2,2-dimethylpropanenitrile, and 3-fluorophenylboronic acid. MS m/z=459.3 [M+H]+. Calculated for C26H23FN4O3: 458.18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012446B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-9d3201fdc04f44fa8c375e623bad5257 |
| Source note | uspto-grants-2015_04 |