3,3-Difluoropyrrolidine hydrochloride → HCID 58465941, compound

HRID 1472481Notes

Reaction equation

HRID 1472481 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[N:28][CH:29]=1.Cl.[F:34][C:35]1([F:40])[CH2:39][CH2:38][NH:37][CH2:36]1>>[F:34][C:35]1([F:40])[CH2:39][CH2:38][N:37]([C:12]2[N:11]=[CH:10][C:9]3[O:8][C:5]4[C:4]([C@:15]5([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]5)[C:14]=3[CH:13]=2)=[CH:3][C:2]([C:26]2[CH:27]=[N:28][CH:29]=[C:24]([F:23])[CH:25]=2)=[CH:7][CH:6]=4)[CH2:36]1

Participants

4

Reactant 3

HCID 249034823,3-Difluoropyrrolidine hydrochlorideHCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 58465879(S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 58465941HCID 58465941, compound

Procedure

The title compound was synthesized by steps analogous to those described in Method A3, but using Intermediate 10B, 5-fluoropyridin-3-ylboronic acid, and 3,3-difluoropyrrolidine hydrochloride. MS m/z=468.3 [M+H]+. Calculated for C24H20FN5O2: 467.16.

Sources & evidence

ORD record
ord-bdfcef1eb0414d96a62934d1f1dcb210
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

Loading…