3,4-Difluorobenzeneboronic acid → HCID 58465940, compound

HRID 1472484Notes

Reaction equation

HRID 1472484 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[N:28][CH:29]=1.[F:33][C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][C:39]=1[F:40]>>[F:33][C:34]1[CH:35]=[C:36]([C:12]2[N:11]=[CH:10][C:9]3[O:8][C:5]4[C:4]([C@:15]5([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]5)[C:14]=3[CH:13]=2)=[CH:3][C:2]([C:26]2[CH:27]=[N:28][CH:29]=[C:24]([F:23])[CH:25]=2)=[CH:7][CH:6]=4)[CH:37]=[CH:38][C:39]=1[F:40]

Participants

4

Reactant 3

HCID 27343373,4-Difluorobenzeneboronic acidHCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 58465879(S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 58465940HCID 58465940, compound

Procedure

The title compound was synthesized by steps analogous to those described in Method A1, but using Intermediate 10B, 5-fluoropyridin-3-ylboronic acid, and 3,4-difluorophenylboronic acid.

Sources & evidence

ORD record
ord-b168e92f47ea4e6fb2fc1edd80c796bc
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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