3,4-Difluorobenzeneboronic acid → HCID 58465889, compound

HRID 1472485Notes

Reaction equation

HRID 1472485 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25](B(O)O)[CH:24]=1.[F:32][C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[CH:37][C:38]=1[F:39]>>[F:32][C:33]1[CH:34]=[C:35]([C:12]2[N:11]=[CH:10][C:9]3[O:8][C:5]4[C:4]([C@:15]5([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]5)[C:14]=3[CH:13]=2)=[CH:3][C:2]([C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)=[CH:7][CH:6]=4)[CH:36]=[CH:37][C:38]=1[F:39]

Participants

4

Reactant 3

HCID 27343373,4-Difluorobenzeneboronic acidHCID 27343783-Pyridinylboronic acidHCID 58465879(S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 58465889HCID 58465889, compound

Procedure

The title compound was synthesized by steps analogous to those described in Method A1, but using Intermediate 10B, pyridin-3-ylboronic acid, and 3,4-difluorophenylboronic acid. MS m/z=457.2 [M+H]+. Calculated for C26H18F2N4O2: 456.14.

Sources & evidence

ORD record
ord-38a98e98df464256acc564ad85a24c39
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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