1-Phenethylamine → HCID 18702324, compound

HRID 1472492Notes

Reaction equation

HRID 1472492 reaction equation
[C:1]1([CH:7]([NH2:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:10]([CH:12]1[O:14][CH2:13]1)Cl>>[C:1]1([CH:7]([NH:9][CH2:10][CH:12]([OH:14])[CH2:13][NH:9][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH3:8])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 74081-PhenethylamineHCID 7835Epichlorohydrin

Product 1

HCID 18702324HCID 18702324, compound

Procedure

The racemate of α-phenylethylamine (1) was used as starting material and condensed with epichlorohydrin in the absence or presence of a solvent to obtain the racemate of 1,3-bis-[(1-phenylethyl)amino]-2-propanol (2) which was then cyclized with cyclizing reagents to give racemic 1,3-oxazolidin-2-one (I). Further reaction with an appropriate acid would give a salt of 1,3-oxazolidin-2-one (I).

Sources & evidence

ORD record
ord-2cdb68fe679e4a8da0607f2288ec367e
Source dataset
uspto-grants-2015_04
Patent number
US09012631B2

Reaction notes

Loading…