Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | HCID 86670200 | HCID 86670200 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Triethylamine tetrahydrofuran | HCID 68616177 | — |
| Product | HCID 70655482 | HCID 70655482 | — |
Reaction Steps
A mixture of 2,3-bis(4-fluorophenyl)-5-iodopyrazine (400 mg, 1.02 mmol, 1.00 equiv), methyl acrylate (1.8 g, 20.93 mmol, 20.62 equiv), CuI (193 mg, 1.02 mmol, 1.00 equiv), Pd(PPh3)Cl2 (285 mg, 0.41 mmol, 0.40 equiv), and tetrahydrofuran/Et3N (2/1 mL) was stirred overnight at 80° C. in an oil bath. The resulting mixture was concentrated in vacuo, and purified via silica gel column chromatography (ethyl acetate/petroleum ether (1:40)) resulting in 120 mg (28%) of (E)-methyl 3-(5,6-bis(4-fluorophenyl)pyrazin-2-yl)acrylate as a grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09012637B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-63e690d52fd940aa9e9c126fafee5e84 |
|---|
| Source note | uspto-grants-2015_04 |
|---|
