HRID1472514

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)c2cnccc2-n2c3ccc(B(O)O)cc3c3cccc1c32

HCID67201981

未命名化合物

结构：CC1(C)c2cnccc2-n2c3ccc(Br)cc3c3cccc1c32

HCID67202177

未命名化合物

PRODUCTS

生成物

结构：CC1(C)c2cnccc2-n2c3ccc(-c4ccc5c(c4)c4cccc6c4n5-c4ccncc4C6(C)C)cc3c3cccc1c32

HCID70665421

未命名化合物

PROCEDURE

实验过程

The compound is synthesised by the same procedure as Example 7 by reaction of 36 g (110 mmol) of 8,8-dimethyl-8H-10,12b-diazabenzo[a]aceanthrylene-3-boronic acid with (110 mmol) of 3-bromo-8,8-dimethyl-8H-10,12b-diazabenzo[a]aceanthrylene. The residue is recrystallised from toluene and from CH2Cl2/isopropanol and finally sublimed in a high vacuum. Yield: 50 g (88 mmol), 80% of theory, purity according to HPLC 99.9%.

WORKUP

后处理

customThe residue is recrystallised from toluene and from CH2Cl2/isopropanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f758a1bf6e6944f1bc3a80e968d146e8
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09012599B2
来源说明: uspto-grants-2015_04

反应 SMILES

[CH3:1][C:2]1([CH3:25])[C:16]2[C:11](=[CH:12][CH:13]=[N:14][CH:15]=2)[N:10]2[C:17]3[C:7]([C:8]4[CH:21]=[C:20](B(O)O)[CH:19]=[CH:18][C:9]=42)=[CH:6][CH:5]=[CH:4][C:3]1=3.Br[C:27]1[CH:48]=[CH:47][C:30]2[N:31]3[C:44]4[C:43]([C:29]=2[CH:28]=1)=[CH:42][CH:41]=[CH:40][C:39]=4[C:38]([CH3:46])([CH3:45])[C:37]1[C:32]3=[CH:33][CH:34]=[N:35][CH:36]=1>>[CH3:1][C:2]1([CH3:25])[C:16]2[C:11](=[CH:12][CH:13]=[N:14][CH:15]=2)[N:10]2[C:17]3[C:7]([C:8]4[CH:21]=[C:20]([C:27]5[CH:48]=[CH:47][C:30]6[N:31]7[C:44]8[C:43]([C:29]=6[CH:28]=5)=[CH:42][CH:41]=[CH:40][C:39]=8[C:38]([CH3:45])([CH3:46])[C:37]5[C:32]7=[CH:33][CH:34]=[N:35][CH:36]=5)[CH:19]=[CH:18][C:9]=42)=[CH:6][CH:5]=[CH:4][C:3]1=3