Hydrogen Bromide → Prasugrel hydrobroMide

Participants

Reaction Conditions

Reaction Steps

To a suspension of 0.499 g of prasugrel base in 5.29 ml of isopropyl acetate/5.5% methanol at 20-25° C., was added dropwise a solution of 0.17 ml 47% HBr(aq) in 1.53 ml of isopropyl acetate/2% methanol. Crystallization occurred to form fluffy crystals. After 45 minutes the resulting suspension was cooled down to 0-5° C. and stirred for about 4 hours. The crystals were filtered off, washed with 1 ml of isopropyl acetate and dried at 40° C./10 mbar for about 17 hours. Prasugrel hydrobromide (0.553 g) was obtained.

Provenance & Evidence