Hydrogen Bromide → Prasugrel hydrobroMide

Participants

Reaction Conditions

Reaction Steps

Prasugrel base (0.51 g) was suspended in 5.0 ml of 1-butanol. A solution of 0.17 ml of 47% HBr (aq) in 2.5 ml of 1-butanol was added to form a clear solution. After 15 minutes at room temperature crystallization started. The resulting suspension was cooled to 0-5° C. and stirred for 1.5 hour. Crystals formed and were filtered, washed with 1-butanol and dried at 50° C./vacuum, yielding 0.53 g of prasugrel hydrobromide.

Provenance & Evidence