Phosphoric Acid → HCID 86680545, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of prasugrel base (1.006 g) in 21.67 ml of methyl acetate/7.7% ethanol at 20-25° C., a dropwise solution of 99% phosphoric acid (329.9 mg) in 2 ml of methyl acetate was added. Crystallization occurred within 30 minutes. After 3 hours at 20-25° C., the suspension was cooled to 0-5° C. and stirred for about 2 hours at that temperature. The obtained crystals were filtered, washed with 4 ml of methyl acetate and dried at 40° C./vacuum for about 1.5 hours. Prasugrel phosphate Form P1 (0.883 g) was obtained.

Provenance & Evidence