HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 2-cyano-3-ethoxy-2-butenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Triethylorthoaceate | HCID 21875354 | — |
| Product | Ethyl 2-cyano-3-ethoxy-2-butenoate | HCID 46635 | — |
Reaction Steps
A mixture of ethyl 2-cyanoacetate (120 g, 1.06 mol) and triethylorthoacetate (354 g, 2.12 mol) in glacial acetic acid (33 g, 0.53 mol) was stirred at 120˜130° C. overnight. The mixture was concentrated under vacuum to provide crude ethyl 2-cyano-3-ethoxybut-2-enoate and carried into the next reaction without further purification assuming 100% conversion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012635B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-0923797829a14054a56cba2d2de2bcfc |
| Source note | uspto-grants-2015_04 |