HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroquinolin-6-ol → 3-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Reactant | 4-(Dihydroxyboranyl)-3-fluorobenzoic acid | HCID 23134177 | — |
| Product | 3-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid | HCID 56961056 | — |
Reaction Steps
Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol and 4-borono-3-fluorobenzoic acid. 1H NMR (CD3OD, 400 MHz): δ 8.31 (d, J=8.4 Hz, 1H), 7.94-7.86 (m, 3H), 7.81-7.74 (m, 2H), 7.35 (dd, J=9.2, 2.8 Hz, 1H), 7.15 (d, J=2.8 Hz, 1H). MS (ESI): m/z 283.6 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012646B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-ae4d806fe4bf47c3981e5969a02b0832 |
| Source note | uspto-grants-2015_04 |