HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1472652Generated: October 30, 2026
4-(4-Chloro-3-fluoro-6-methoxyquinolin-2-yl)benzoic acid → 4-(3-Fluoro-6-methoxyquinolin-2-yl)benzoic acid
https://huagongshe.com/reaction/1472652
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(4-Chloro-3-fluoro-6-methoxyquinolin-2-yl)benzoic acid | HCID 66980085 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(3-Fluoro-6-methoxyquinolin-2-yl)benzoic acid | HCID 66980078 | 66% |
Reaction Steps
To a solution of the mixture from Step 1 in absolute MeOH (5 mL) was added Pd/C (10% Pd, 100 mg). The mixture was stirred at 25° C. for 1 hour under H2 atmosphere. The solids were filtered off and the filtrate was concentrated to give the product (60 mg, two-step yield 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09012646B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-482bca3b3cbb49699fb69bd8b6c69de1 |
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| Source note | uspto-grants-2015_04 |
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