HuagongsheHuagongshe Chemistry Print Report · For research reference only
Simtuzumab → 3-Chloro-4-(6-hydroxyquinazolin-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Simtuzumab | HCID 17750227 | — |
| Reactant | 2-Chloro-6-methoxyquinazoline | HCID 59254852 | — |
| Product | 3-Chloro-4-(6-hydroxyquinazolin-2-yl)benzoic acid | HCID 57407159 | — |
Reaction Steps
Prepared according to Scheme 6, B conditions, starting from Intermediate 8 and 4-carboxy-2-chlorophenylboronic acid. 1H NMR (DMSO-d6 400 MHz): δ 10.60 (brs, 1H), 9.56 (s, 1H), 8.10-7.89 (m, 4H), 7.62 (dd, J=9.2, 2.8 Hz, 1H), 7.38 (d, J=2.8 Hz, 1H). MS (ESI): m/z 300.8 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012646B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-3cfd70826d3c40f6a398ce0c7c924280 |
| Source note | uspto-grants-2015_04 |