HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1472729Generated: October 30, 2026
Potassium Hydroxide → 1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile
https://huagongshe.com/reaction/1472729
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 2,2-Difluoro-1,3-benzodioxole-5-acetonitrile | HCID 20311384 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile | HCID 57446150 | — |
Reaction Steps
A mixture of compound 20 (1.0 eq), 50 wt % aqueous KOH (5.0 eq) 1-bromo-2-chloroethane (1.5 eq), and Oct4NBr (0.02 eq) is heated at 70° C. for 1 h. The reaction mixture is cooled then worked up with MTBE and water. The organic phase is washed with water and brine then the solvent is removed to afford compound 21.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09012652B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-c219fdad44d64926996fcc610f92adf4 |
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| Source note | uspto-grants-2015_04 |
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