HCID 71093203, compound → 3193-25-7

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of ethyl 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetate (1.06 g, 4.02 mmol) in THF (10 mL), sodium hydroxide (10 mL, 2.0 M aqueous solution) was added. The reaction was heated at 60° C. for 24 hours. The reaction was allowed to cool to RT, and THF was removed under reduced pressure. The resultant residue was washed with diethyl ether (×3). The aqueous layer was acidified to pH 1 with 2.0 M aqueous hydrochloric acid and extracted with ethyl acetate (×3). The combined ethyl acetate layers were washed with saturated sodium chloride solution, dried (magnesium sulfate), filtered and concentrated in vacuo to afford the title compound (0.75 g, 79%).

Provenance & Evidence