Hydrochloric Acid → Piperidin-4-ylmethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride

Participants

Reaction Steps

tert-Butyl 4-((2-cyclohexyl-2-hydroxy-2-phenylacetyloxy)methyl)-piperidine-1-carboxylate (1.10 g, 2.55 mmol) was dissolved in hydrochloric acid (5 mL, 4 M solution in dioxane) and dichloromethane (5 mL). The reaction mixture was stirred at RT for 3 hours and concentrated under reduced pressure to afford the title compound (970 mg, >100%) that was used without further purification in the next step.

Provenance & Evidence