p-Toluenesulfonic acid monohydrate → HCID 86676456, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 4-((2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetyloxy)methyl)piperidine-1-carboxylate (0.84 g, 1.94 mmol) in acetonitrile (10 mL), p-toluenesulfonic acid monohydrate (0.55 g, 2.91 mmol) was added. The reaction was stirred at 30° C. overnight and then concentrated under reduced pressure to afford the title compound (1.17 g, >100%) that was used without further purification in the next step.

Provenance & Evidence