HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromopyridine-2-carbaldehyde → 6-(4-(Trifluoromethyl)phenyl)picolinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromopyridine-2-carbaldehyde | HCID 2757009 | — |
| Reactant | 6-Bromo-3-fluoropyridine-2-carbaldehyde | HCID 16414238 | — |
| Reactant | 2-(Trifluoromethyl)pyridine-5-boronic Acid | HCID 25134278 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-(4-(Trifluoromethyl)phenyl)picolinaldehyde | HCID 24730089 | — |
Reaction Steps
The title compound was prepared using procedure similar to that described for Example 28A, substituting 4-(trifluoromethyl)phenylboronic acid for 6-(trifluoromethyl)pyridin-3-ylboronic acid and 6-bromopicolinaldehyde for 6-bromo-3-fluoropicolinaldehyde. MS (ESI+) m/z 283.9 (M+H+MeOH); 1H NMR (300 MHz, DMSO-d6) δ 10.09 (s, 1H), 8.46-8.38 (m, 3H), 8.21 (t, J=7.7, 1H), 8.00-7.89 (m, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012651B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-2d7acec76413473aa5cd9235be820b5c |
| Source note | uspto-grants-2015_04 |