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HRID1472903

反应详情

EQUATION

反应方程式

HRID 1472903 的结构方程式

REACTANTS

反应物

2
结构：OB(O)C1=CC2CCC1C2
HCID44119810

Bicyclo[2.2.1]hept-2-en-2-ylboronic acid

C7H11BO2

结构：CC(C)[C@H](CO)NCc1nc(C2=CCC(C)(C)CC2)ccc1F
HCID68312544

未命名化合物

PRODUCTS

生成物

2
结构：CC(C)[C@H](CO)NCc1nc(C2CCC(C)(C)CC2)ccc1F
HCID68312355

未命名化合物

结构：CC(C)[C@H](CO)NCc1nc(C2=CCC(C)(C)CC2)ccc1F
HCID68312544

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Pd]
催化剂HCID23938

Palladium

Pd

PROCEDURE

实验过程

(R)-2-(((6-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoropyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was prepared according to Example 199, substituting 2-(4,4-dimethylcyclohex-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane for bicyclo[2.2.1]hept-2-en-2-ylboronic acid. (R)-2-(((6-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoropyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was subjected to hydrogenation (H2 atmosphere, Pd/C catalyst) to provide the title compound. MS (ESI+) m/z 323 (M+H)+.