Bicyclo[2.2.1]hept-2-en-2-ylboronic acid → HCID 68312496, compound

Participants

Reaction Steps

(R)-2-(((3-fluoro-6-(1,4-dioxaspiro[4.5]dec-7-en-7-yl)pyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was prepared according to Example 199, substituting 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-7-yl)-1,3,2-dioxaborolane for bicyclo[2.2.1]hept-2-en-2-ylboronic acid. (R)-2-(((3-fluoro-6-(1,4-dioxaspiro[4.5]dec-7-en-7-yl)pyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was subjected to hydrogenation (H2 atmosphere, Pd/C catalyst) to provide the title compound. MS (ESI+) m/z 353 (M+H)+.

Provenance & Evidence