HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bicyclo[2.2.1]hept-2-en-2-ylboronic acid → HCID 68312431, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bicyclo[2.2.1]hept-2-en-2-ylboronic acid | HCID 44119810 | — |
| Reactant | HCID 68312606 | HCID 68312606 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 68312431 | HCID 68312431 | — |
| Product | HCID 68312606 | HCID 68312606 | — |
Reaction Steps
(2R)-2-(((3-fluoro-6-(4-(trifluoromethyl)cyclohex-1-en-1-yl)pyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was prepared according to Example 199, substituting 4,4,5,5-tetramethyl-2-(4-(trifluoromethyl)cyclohex-1-enyl)-1,3,2-dioxaborolane for bicyclo[2.2.1]hept-2-en-2-ylboronic acid. (2R)-2-(((3-fluoro-6-(4-(trifluoromethyl)cyclohex-1-en-1-yl)pyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was subjected to hydrogenation (H2 atmosphere, Pd/C catalyst) to provide the title compound. MS (ESI+) m/z 363 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012651B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-06ba87c20a83456fa14b547686e51b3d |
| Source note | uspto-grants-2015_04 |