Bicyclo[2.2.1]hept-2-en-2-ylboronic acid → HCID 68312578, compound

Participants

Reaction Steps

(R)-tert-butyl 4-(5-fluoro-6-(((1-hydroxy-3-methylbutan-2-yl)amino)methyl)pyridin-2-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate was prepared according to Example 199, substituting tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate for bicyclo[2.2.1]hept-2-en-2-ylboronic acid. (R)-tert-butyl 4-(5-fluoro-6-(((1-hydroxy-3-methylbutan-2-yl)amino)methyl)pyridin-2-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate was subjected to hydrogenation (H2 atmosphere, Pd/C catalyst) to provide the title compound. MS (ESI+) m/z 2813 (M+H)+.

Provenance & Evidence