反应详情

温度

80 °C

To a solution of 6-bromopicolinaldehyde (1.00 g, 5.38 mmol) in dioxane (30 mL) at ambient temperature was added 4-fluoro-3-(trifluoromethyl)phenylboronic acid (1.11 g, 5.38 mmol), 2M cesium carbonate (8.0 mL, 16 mmol) and 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (0.220 g, 0.269 mmol). The mixture was degassed (3× vacuum/purge N2), then heated at 80° C. overnight. After cooling to room temperature the mixture was concentrated and the residue partitioned between water and CH2Cl2. The organic extract was concentrated and purified by chromatography (10% ethyl acetate:hexanes) to provide 1.31 g (91%) of the title compound. MS (DCI+) m/z 270 (M+H).

1. customThe mixture was degassed
2. custom(3× vacuum/purge N2)
3. temperatureAfter cooling to room temperature the mixture
4. concentrationwas concentrated
5. customthe residue partitioned between water and CH2Cl2
6. extractionThe organic extract
7. concentrationwas concentrated
8. custompurified by chromatography (10% ethyl acetate:hexanes)