反应详情

The general procedure 1 was then followed using the above product (7.14 mmol, 1.7 g), ethyl-2-(1H-indol-3-yl)-2-oxoacetate (4.6 mmol, 1.0 g) and Cs2CO3 (9.21 mmol, 3.0 g). The purification was achieved by column chromatography (petrol-ether:ethylacetate 1:1) to yield ethyl-2-(1-{3-[(tert.-butoxycarbonyl)amino]propyl}-1H-indol-3-yl)-2-oxoacetate (5.3 mmol, 74%) as pale yellow crystals. Mp 89-90° C. IR {tilde over (ν)} [cm−1]=3392; 2977; 2936; 1727; 1698; 1619; 1515. EI-MS m/z (rel. int.)=374 (8.9%; M+•.). 1H NMR (300 MHz, CDCl3) 8.45 (m; 2H; indole-H); 7.35 (m; 3H; indole-H); 4.63 (bs; 1H; NH); 4.41 (q; 3J=7.1 Hz; 2H; OCH2CH3); 4.24 (t; 3J=7.1 Hz; 2H; indole-CH2); 3.18 (q; 3J=6.1 Hz; 2H; CH2N); 2.09 (m; 2H; CH2CH2CH2); 1.44 (s; 9H; C(CH3)3); 1.43 (t; 3J=7.1 Hz; 3H; OCH2CH3).

1. customThe purification