Potassium Carbonate → HCID 67362893, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 15α-acetoxy-3-methoxy-18-methyl-estra-3,5-dien-17-one (1 g, 2.8 mmol) in suspension in a 1/1 MeOH/water solution (20 ml), and potassium carbonate (1 g, 7.23 mmol) was heated at 50° C. for 1 h. The mixture was allowed to cool to room temperature and the precipitate was filtered, washed with water and dried under vacuum to afford 3-methoxy-18-methyl-estra-3,5,15-trien-17-one (0.67 g, yield: 80%). mp: 159-161° C.; 1H-NMR δ=0.72 (t, 3H), 0.9-2.4 (m, 16H), 3.55 (s, 3H), 5.18 (s, 1H), 5.28 (d, 1H), 5.95 (m, 1H), 7.45 (d, 1H).

Provenance & Evidence