Water → HCID 67369411, compound

Participants

Reaction Conditions

Reaction Steps

Triethylamine (0.5 ml, 3.6 mmol) was added to a suspension of 15α-acetoxy-6-chloro-18-methyl-estra-4-en-3,17-dione (0.5 g, 1.32 mmol) in ethanol (15 ml). The mixture was stirred at 45° C. for 2 h, cooled to 10° C. and water (4 ml) was then added. The precipitate was filtered and washed with an ethanol/water (1/1) mixture. The crude product was crystallized from ethanol and dried under vacuum to afford 6-chloro-18-methyl-estra-4,15-dien-3,17-dione (0.26 g, yield: 62%).

Provenance & Evidence