Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 67362263, compound

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Reaction Conditions

Reaction Steps

A suspension of 15α-acetoxy-18-methyl-estr-4-en-3,17-dione (48 g, 139 mmol) and pyridinium p-Toluenesulfonate (4.8 g, 19.1 mmol) in 2,2-dimethoxypropane (400 ml) was refluxed for 6 h. The mixture was then cooled to −10° C. for 2 h. The precipitate was filtered, washed with cooled methanol and dried under vacuum to afford 15α-acetoxy-3-methoxy-18-methyl-estra-3,5-dien-17-one (42.7 g, yield: 86%).

Provenance & Evidence